![]() ![]() Mosby's Diagnostic and Laboratory Test Reference. Pagana, Kathleen Deska Pagana, Timothy J. “Elevated mean platelet volume predicts poor prognosis in colorectal cancer.” Scientific reports vol. ![]() “Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: A case control study.” Journal of cardiovascular disease research vol. “Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis.” Platelets vol. “Mean platelet volume: a link between thrombosis and inflammation?.” Current pharmaceutical design vol. "Mean platelet volume and mean platelet volume/platelet count ratio as a risk stratification tool in the assessment of severity of acute ischemic stroke." Alexandria journal of medicine 53.1 (2017): 67-70. “Usefulness of a complete blood count-derived risk score to predict incident mortality in patients with suspected cardiovascular disease.” The American journal of cardiology vol. “Association of serum total bilirubin level with severity of coronary atherosclerosis is linked to systemic inflammation.” Atherosclerosis vol. Further assessment of cardiac risk factors would be prudent with an MPV at this level.Ĭolorectal cancer patients with an MPV above 8.6 fL had increased tumor differentiation and significantly worse prognosis than those with 8.6 fL or below (Li 2017).Īkboga, Mehmet Kadri et al. In one meta-analysis of 40 observational studies, an MPV of 7.3 fL or higher was associated with increased risk of coronary artery disease, with a level of 7.7 fL or higher increasing risk by two-fold (Sansanayudh 2014). An MPV of 8.2 fL was associated with diabetes, with risk increasing most significantly with an MPV of 9.31 fL or greater (Shah 2012). Mean platelet volume above 8.2 fL is associated with significantly greater risk of deep vein thrombosis (Han 2013). In hypertensive individuals, a higher mean platelet volume was linked to risk of cardiovascular complications including myocardial infarction, stroke, and left ventricular hypertrophy (Anderson 2007). However, a tighter range would be more appropriate as an MPV of 8.5 fL was associated with mild CAD and a level of 8.7 was associated with severe CAD, while controls maintained a level of 8.3 (Akboga 2015).Įlevated MPV may increase risk of a number of chronic diseases. An MPV cut-off of 9.25 was recommended for predicting acute MI in a case-control study of 128 subjects, while a cut-off of 9.15 was recommended for identifying stable coronary artery disease (Khode 2012). In patients with atrial fibrillation, an MPV of greater than 9.4 fL was associated with a significantly greater occurrence of stroke (Turfan 2013). An MPV greater than 8.1 fL increases risk of ischemic stroke (Elsayed 2017). These larger platelets are more active and reactive, more aggregative, and produce more prothrombotic factors and thromboxane A2 which promotes vasoconstriction. However, MPV will be high if the bone marrow is functional and is attempting to increase platelet production but releases larger immature platelets, e.g., in thrombocytopenia (Pagana 2019). ![]() The MPV will be low, and platelets will be smaller, when bone marrow production is inadequate. Mean platelet volume is dependent on bone marrow production of platelets, the small blood cells that facilitate clotting. An elevated level may also be associated with thrombosis, increased vascular risk, more severe ischemic stroke, myocardial infarction, diabetes, metabolic syndrome, hypercholesterolemia, renal artery stenosis (Elsayed 2017), and chronic low-grade inflammation (Gasparyan 2011). High MPV is associated thrombocytopenia, massive hemorrhage, myelogenous leukemia, valvular heart disease, and B12 or folate deficiency (Pagana 2019). Active rheumatoid arthritis and other conditions associated with high-grade inflammation are also associated with lower MPV (Gasparyan 2011). ![]() Low MPV can be associated with aplastic anemia, chemotherapy, and Wiskott-Aldrich syndrome (Pagana 2019). A low MPV may be associated with aplastic anemia and chemotherapy treatment. An increasing MPV indicates that production is accelerated but results in larger, immature, and more reactive platelets, increasing risk of complications. The MPV reflects the average size, as well as production and release, of platelets from the bone marrow. Mean platelet volume (MPV) is part of the complete blood cell count (CBC). ![]()
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